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Aloe Vera Research

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Aloeride aloe vera researchAloe vera has been valued throughout the ages and this documented empiricism dates back to well before Christ. Science saved us from subjective enthusiasm which is why aloe vera became probably one of the most researched herbs on the planet. The plethora of good quality aloe vera research on generic aloe vera has shown that it offers physiological support in the following areas:

  • Digestive system
  • Immune system
  • Skeletal system
  • Skin and hoof health
  • Effect On Cell Growth
  • Effect On Hoof Growth

What researchers found depended on the molecules being present in the (generic) aloe vera substrate they tested with. From the independent laboratory studies that we initiated on a large number of aloe vera consumer products it is clear that quality and quantity often are compromised.

We believe the following to be reasonable: 1) thanks to biochemistry and physiology (of nutrition) there’s no mystery as to what molecular constituents within aloe vera do; 2) for ‘doing’ to manifest in real life, food/feed or in the case of Aloeride food/feed supplements must deliver meaningful quantities of such molecular constituents; 3) when one delivers verified quality in meaningful, absorbable dosage then happy customers will recommend a product to their friends. There is a lot of positive chat about Aloeride.

GASTROINTESTINAL EFFECT:

  • Bland, J.; Effect of orally consumed Aloe Vera juice on gastrointestinal function in normal humans. Linus Pauling Institute of Science & Medicine Palo Alto, C.A. Prevention Magazine. 1985.
  • Blitz, J.J.; Smith, J.W.; Gerard, J.R. Aloe Vera Gel in peptic ulcer therapy; Preliminary report. Journal of the American Osteopathic Association. 1963.62.731-735.
  • Che, Q.M.; Akoe, T.; Hattori, M.; Kobashi, K.; Namba, T. isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. Planta Med, 1991 Feb. 57(1). 15-19.
  • Galalee, Kandila, Hegazy E, El Ghoroury M, Gobran W: Aloe Vera and gastrointestinal ulceration, J Drug Res Egypt 7:73-77, 1975.
  • Gupta MB, Nath R, Gupta GP, Bhargava KP: Antiulcer activity of some plant triterpenoids, Indian J Med Res 73:649-652, 1981.
  • Kandil A, Gobran W: Protection of gastric mucosa by Aloe Vera, J Drug Res Egypt 11:191-196, 1979.
    Koo, M.W.L. Aloe Vera; anti-ulcer and anti-diabetic effects. Phytother Res. 1994. 8(8). 461-464.
  • Savitskii VI: The effect of tissue preparations on the biochemical processes of the body, In: The use of tissue preparations in animal husbandry and veterinary medicine, Urozhai, Kiev ():31-41,1966. From: Ref Zh Otd Vyp Farmakol Khimioter Sredstva Toksikol, No. 6, 54638, 1967.
  • Solov’Eva VP: Effect of Aloe extract on some biochemical indicators of normal and sick persons. Vrachebnoe Delo ():93-98, 1958.
  • Suga T, Hirate T: The efficacy of the Aloe plants chemical constituents and biological activities. Cosmet & Toil 98:105-108, 1983.

ANTI-INFLAMMATORY EFFECT:

  • Bradshaw, T.W. Aloe Vera: its influence on the physiology of wound healing and inflammation. J. Brit. Pod. Med. 1996. 51(2). 25-29. A7.
  • Brasher, W.J.; Zimmermann, E.R.; Collings, C.K. The effects of Prednisolone, Indomethacin and Aloe Vera Gel on tissue culture cells, oral surgery, oral medicine and oral pathology. 1969. 27. 122-128.
  • Davis, R.H.; Agnew, P.S.; Shapiro, E. Antiarthritic activity of anthraquinones found in Aloe for podiatric medicine. J. Am. Podiatric Med. Assoc. 1986. 76(2) 61-66.
  • Davis, R.H.; Leitner, M.E.; Russo, J.M. Topical anti-inflammatory activity of Aloe Vera as measured by ear swelling. J. Am. Podiatric. Med. Assoc. 1987. 77(11) 610-612.
  • Davis, R.H.; Leitner, M.G.; Russo, J M.; Byrne, M.E. Anti-inflammatory activity of Aloe Vera against a spectrum of irritants. (oral activity found to be dependent on presence of Anthraquinones). J. AM. Podiatric Med. Assoc (US). 1989 June. 79 (6). 263-276.
  • Davis. R.H.; Maro, N.P. Aloe Vera and gibberellin. Anti-inflammatory activity in diabetes. J. Am. Podiatric Med. Assoc. 1989 Jan. 79 (1). 24-26.
  • Davis, R.H.; Rosenthal, K.Y.; Cesario, L.R.; Omu, G.A. Processed Aloe Vera administered topically inhibits inflammation. J. Am. Podiatric Med. Assoc. 1989. 79(8). 395-397.
  • Davis, R.H.; Stewart, G.J.; Bregman, P.J. Aloe Vera and the inflamed synovial pouch model. J. Am. Podiatric Med. Assoc. 1992 Mar. 82 (3). 140-148.
  • Davis, R.H.; Didonato, J.J.; Hartman, G.M.; Haas, R.C. Anti-inflammatory and wound healing activity of a growth substance in Aloe Vera. J. Am. Podiatric Med. Assoc. 1994 Feb. 84(2). 77-81.
  • Davis, R.H.; Didonato, J.J.; Johnson, R.W.; Stewart, C.B. Aloe Vera, hydrocortisone and sterol influence on wound tensile strength and anti-inflammation. J. Am. Podiatric Med. Assoc. 1994 Dec. 84(12). 614-621.
  • Fujita, K.; Teradoura, R.; Nagatsu, T. Bradykiase activity of Aloe extract. Biochemical Pharmacology. 1976. 25. 205.
  • Fujita, K.; Ito, S.; Teradaira, R.; Beppu, H. Properties of carboxypeptidase from Aloe. Biochemical Pharmacology. 1979. 28 1261-1262.
  • Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, Weintraub ST: Anti-inflammatory C-glucosyl chromone from Aloe barbadensis, J Natural Prod 59:541-543, 1996.
  • Ibo, S.; Teradaira, R.; Beppu, H.; Obata, M.; Nagatsu, T.; Fujita, K. Properties and pharmacological activity of carboxypeptidase in Aloe arborescens Miller var. natalensis Berger. International Congress of Phytotherapy. 1991 Oct. Seoul, Korea. 39.
  • Ibo, S; Teradaira R; Beppu, H; Obata. M; Fijita K; Nagabsu, T. Biochemical properties of carboxypeptidase from Aloe arborescens Miller var. natalensis Berger. Phytotherapy Research. 1993. 7. No special issue. S26-29.
  • Nakagomi, K.; Oka, S.; Tomizuka, N.; Yamamoto, N.; Masui, T.; Nakazawa, H. A novel biological activity in Aloe components effects on mast cell degranulation and platelet aggregation. Rep. Ferment Res. Inst. (Yakabie)
  • Obata, M.; Obp, S.; Beppu, H.; Fujita, K.; Nagatou, T. Mechanism of anti-inflammatory and antithermal burn action of Cpase from Aloe arborescens Miller var natalensis Berger in rats and mice. Phytother. Res. 1993. 7. Special issue. 530-533.
  • Vamamoto, M.; Sugyama, K.; Voketa, M.; Maeda, Y.; Nakagomi, K.; Nakazawa, H. Inhibitory effects of Aloe extracts on antigen and compound 48-80 induced histamine release from rat peritoneal mast cells. Japanese Journal of Toxicology and Environmental Health. 1993. 39(5). 395-400.
  • Vazquez B, Avila G, Segura D, Escalante B: Anti-inflammatory activity of extracts from Aloe Vera Gel. J Ethnopharmacol 55:69-75, 1996.
  • Yagi A, Harada N, Sminomura K, Nishioka I: Bradykinin-Degradin glycoprotein in Aloe arborescens var. Natalensis. Planta Med 53:19-21, 1987.

ANTI-MICROBIAL EFFECT:

  • Andersen, D.C.; Weber, N.D.; Wood, S.G.; Hughes, B.G.; Murray, B.K.; North, J.A. In vitro virucidal activity of selected Anthraquinones and Anthraquinone derivatives. Antiviral. Res. 1991. Sep. 16(2). 185-96.
  • Gottshall, R.Y.; Jennings, J.C.; Weller, L.E. et al. Anti-bacterial substances in seed plants active against tubercle bacilli. Am. Rev. Tuberc. 1950. 60. 475-480.
  • Kahlon, J.B.; Kemp, M.C.; Yawei, N.; Carpenter, R.H.; Shannon, W.M.; McAnalley, B.H. In-vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothynidine and acyclovir. Mol. Biother. 1991. 3. 214-223.
  • Lorenzetti, L.J.; Salisbury, R.; Beal, J.L.; Baldwin, J.N. Bacteriostatic property of Aloe Vera. Journal of Pharmaceutical Science. 1984. 53. 1287.
  • Sheets, M.A.; Unger, B.A.; Giggleman, G.F.; Tizard, I.R. Studies of the effect of acemannan on retrovirus infections: clinical stabilization of feline leukaemia virus-infected cats. Mol. Biother. 1991. 3. 41-45.
  • Sims, R.M.; Zimmerman, E.R. Report on effect of Aloe Vera on growth against Trichomonas Vaginalis, Dallas Microb – Assay Service. Aloe Vera of America Archives, Stabilized Aloe Vera. 1971. 1. 241-242.
  • Sims, Ruth M.; E.R. Zimmerman Report – The Effect of Aloe Vera on Mycotic Organisms (Fungi) Aloe Vera of America Archives. Stabilized Aloe Vera. 1971 . 1. 239-240.
  • Sydiskis; Owen; Lohr; Rosler; Blomster. Inactivation of Herpes simplex virus by Anthraquinones isolated from plants. J Dental Res. 1989 June. 68. 935.
  • Syed T.A; Afsal, M.; Ashfa, Q.; Ahmed, S.; Holt, A.N.; Ahmed Ali S.; Ahmed, S.H. Management of genital herpes in men with 0.5% Aloe Vera extract in a hydrophilic cream: a placebo controlled double blind study. J. of Dermatological. 1997.8.99-102.

WOUND HEALING:

  • Bishop, J.B.; Phillips, L.G.; Musbore, T.A. et. Al. A prospective randomised evaluation – blinded trial of two potential woundhealing agents for the treatment of venous stasis ulcers. J. Vasc. Surg. 1992. 16. 251-257.
  • Bradshaw, T.W. Aloe Vera; its influence on the physiology of wound healing and inflammation. J. Brit. Pod. Med. 1996. 51(2). 25-29.
  • Davis, R.H.; Leitner, M.G.; Russo, J.M.; Byrne, M.E. Wound healing, oral and topical activity of Aloe Vera. J. Am. Podiatric Med. Assoc. 1989 Nov, 79(11). 559-562.
  • Davis, R.H.; Parker, W.L.; Samson, R.T.; Murdoch, D.S. Isolation of a stimulatory system in aloe extract. J. Am. Podiatric Med. Soc. 1991 Sept. 81(9) 473-477.
  • Davis, R.H.; Didonato, J.J.; Hartman, G.M.; Haas, R.C. Antiinflammatory and wound healing activity of a growth substance in Aloe Vera, J. Am. Podiatric. Med. Assoc. 1994 Feb. 84(2). 77-81.
  • Davis; Kabbani; Maro. Aloe Vera and wound healing. Special emphasis to combination with RNA and Vit. C., consideration of part played by Anthraquinones. J. Am. Podiatric Med. Assoc. 1987. 77(4). 165-169.
  • El Zawahry, M.; Hegarty, M.R.; Helal, M. Use of Aloe in treating leg ulcers and dermatoses. International J. of Dermatology. 1973. 12. 68-73.
  • Fulton, J.E. the stinulation of postdermabrasion wound healing with stabilised Aloe Vera gel-polyethylene oxide dressing. J. Dermatol Surg. Oncol. 1990 May. 16(5). 460-467.
  • Heggers, J.P.; Kucukcelebi, A.; Listengarten, D.; Stabenau, J.; Ko, F.; Broemeliing, L.D.; Robson, M.C.; Winters, W.D. Beneficial effect of Aloe on wound healing in an excisional wound model. J. of Alternative and Complementary Medicine. 1966. 2(2). 271-277.
  • Heggers, J.P.; Robson, M.C. Beneficial effects of Aloe in wound healing. International Congress of Phytotherapy. 1991 Oct. Seoul, Korea. 27.
  • Heggers, J.P.; Pelley, R.P.; Robson, M.C. Beneficial effects of Aloe in wound healing. Phytother. Res. 1993.&. No special issue. S48-52.
  • Heggers, J.P.; Haussam, E.; Garfield, R. et. Al. Effect of the combination of Aloe Vera, nitroglycerin and L-NAME on wound healing in the rat excisional model. J. or alternative and Complementary Medicine. 1997. 3(2). 149-153.
  • Kaufman, T.; Kalderom, N.; Ullmann, Y.; Berger, J. Aloe Vera gel hindered wound healing of experimental second-degree burns; a quantitative controlled study. J. Burn Care Rehabil. 1988 Mar-Apr. 9(2), 156-159.
  • Miller, M.B.; Koltai, P.J. Treatment of experimental frostbite with pentoxifylline and Aloe Vera cream. Arch. Otolaringol Head Neck Surg. 1995 June. 121(6). 678-680.
  • Schmidt, J.M.; Greenspoon, J.S. Aloe Vera dermal wound gel is associated with a delay in wound healing. Obstet, Gynaecol (US) 1991 July. 78(1). 115-117.
  • Thomlinson, R.H. Kitchen Remedy for Necrotic Malignant Breast Ulcers. Lancet. 1980. 2: 707.
  • Tizard, I.R.; Maxwell, B.; Kemp, M.C. et. Al. Accelerated wound healing induced by macrophage stimulants in rats; a genetically controlled phenomenon. Wound Repair and regeneration. 1993. 1. 130.

USE IN BURNS:

  • Cera, L.M.; Heggers, J.P.; Robson, M.C.; Hagsbrern, W.J. The therapeutic efficacy of Aloe Vera cream dermaide Aloe in thermal injuries 2 cases. J. Am. Anim. Hosp. Assoc. 1980. 16(5). 768-772.
  • Cera, L.M.; Heggers, J.P.; Hagstrom, W.J.; Robson, M.C. Therapeutic protocol for chemically injured animals and its successful use in an extensively burned rhesus monkey. Journal of the American Animal Hospital Association. 1982. 18. 633-638.
  • Collins, C.E.; Collins, C. Roentgen dermatitis treated with fresh whole leaf of Aloe Vera. American Journal of Reoentgenology. 1935. 33. 396-397.
  • Obata, M.; Ibo, S.; Beppu, H.; Fujita, K.; Nagatou, T. Mechanism of anti-inflammatory and antithermal burn action of Cpase from Aloe arborescens Miller var natalensis Berger in rats and mice. Phytother. Res. 1993. 7. Special issue. 530-533.
  • Rodriguez-Bigas, M.; Cruz, N.I.; Suarez, A. Comparative evaluation of Aloe Vera in the management of burn wounds in guinea pigs. Plast. Reconstr, Surg. (U.S.) 1988. 81(3). 386-389.
  • Rowe, T.D. Effect of Fresh Aloe Vera Jelly in the Treatment of Third-Degree Roentgen Reactions on White Rats. Journal of the American Pharmaceutical Association. 1940. 29. 348-350.
  • Williams, M.S.; Bink, M.; Loprimzi, C.L.; et. Al/ Phase 111 doubleblind evaluation of the Aloe Vera gel as a prophylactic agent for radiation induced skin toxicity. Int. J. Radiat. Oncol-Biol-Phys. 1996 Sept. 36(2). 345-349.

EFFECT ON CELL GROWTH:

  • Bouthet, C.F.; Schirf, V.R.; Winters, W.D. Stimulation of neuron like cell growth of Aloe substances. Phytother. Res. 1995. 9. 185-188
  • Brasher, W.J.; Zimmermann, E.R.; Collings, C.K. The effects of Prednisolone, Indomethacin and Aloe Vera Gel on tissue culture cells, oral surgery, oral medicine and oral pathology. 1969. 27. 122-128.
  • Danhof I.E.; McAnalley, B.H. Stabilised Aloe Vera – effect on human skin cells Drug & Cosmetic Industry. 1983. 133. 52,54,105-106
  • Jeong, H.Y.; Kim, J.H.; Hwang, S.J.; Rhee, D.K. Anticancer effects of Aloe on sarcoma 180 in ICR mouse and on human cancer cell lines. Yakhak Hoeji. 1994. 38(3). 311-321.
  • Sendelbach, L.E. A Review of the toxicity and Carcinogenicity of Anthraquinone derivatives. Toxicology 1989. 57.227-240.
  • Westendorf; Marquardt; Poginsky; Dominiak; Schmidt. Genotoxicity of naturally occurring Hydroxyanthraquinones. Evaluation of mutagenicity and cell-transforming activity. Mutat. Res. 1990 Jan. 240(1). 1-12.
  • Winters, W.D.; Benavides, R.; Clouse, W.J. Effects of Aloe Extracts on Human Normal and Tumor Cells in Vitro. Econ. Bot. 1981. 35: 89-95.

IMMUNOMODULATION:

  • Green P. Aloe Vera extracts in equine clinical practice. Veterinary Times. 1996 Sept. 26(9) 16.
  • Harris, C.; Pierce, K.; King, G.; Yates, K.M.; Hall, J.; tizard, I. Efficacy of acemannan in treatment of canine and feline spontaneous neoplasms. Mol. Biother. 1991. 3. 207-213.
  • Hart, L.A.; van Emckevort, P.H; van Dijk, H.; Faat, R; de Silva, K.T.; Labodie, R.P. Two functionally and chemicallyu distinct immunomodulatory compounds in the gel of Aloe Vera. J. Ethnopharmacol. 1988 May-Jun. 23(1). 61-71.
  • Imanishi, Keni Chi. Aloctin A, an active substance of Aloe arborescens as an immunomodulator. International Congress of Phytotherapy. 1991 Oct. Seoul. Korea 34.
  • Imanishi, Kimichi, Aloctin, A. An active substance of Aloe arborescens as an immunomodulator. Phytother Res. (1993) 7 (spec. Issue). Proceedings of the International Congress of Phytotherapy. 1991. S20-22.
  • Kahlon, J.B.; Kemp, M.C.; Yawei, N.; Carpenter, R.H.; Shannon, W.M.; McAnalley, B.H. In-vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir. Mol. Biother. 1991. 3. 2140223.
  • Karaca, K.; Sharma, J.M.; Nordgren, R. Nitric Oxide production by chicken macrophages activated by acemannan, a complex carbohydrate extracted from Aloe Vera. International Journal of Immunopharmacology. 1993. 17(3). 183-188.
  • Marshall, G.D.; Druck, J.P. In vitro stimulation of NK activity by acemannan (ACM). J. Immunol. 1993. 150. 1381.
  • Marshall, G.D.; Gibbons, A.S.; Parnell, L.S. Human cytokines induced by acemannan. J. Allergy Clin. Immunol. 1993. 91.295.
  • McDaniel, H.R.; McAnalley, B.H. Evaluation of polymannoacetate (Carrisyn) in the treatment of AIDS. Clin. Res. 1987. 35. 483A.
  • Pugh N, Ross SA, ElSohly MA, Pasco DS.; Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J. Agric Food Chem. 2001 Feb;49(2):1030-4.
  • Sheets, M.A.; Unger, B.A.; Giggleman, G.F.; Tizard, I.R. Studies of the effect of acemannan on retrovirus infections; clinical stabilization of feline leukaemia virus-infected cats. Mol. Biother. 1991. 3. 41-45.
  • Tizard, I.; Carpenter, R.H.; Kemp, M. Immuno-regulatory effects of a cytokine release enhancer (acemannan). International congress of Phytotherapy 1991 Oct Seoul, Korea 68.
  • Winters; Wendell. Immunoreactive lectins in leaf gel from Aloe Barnadensis Miller. Phytother. Res. 1993. 7. Apec. Issue, Proceedings of the International Congress of Phytotherapy. 1991. S23-25.
  • Womble. D.; Helderman, J.H. The impact of acemannan on the generation and function of cytotoxic T-lymphocytes. Immunopharmacol Immunotoxicol. 1992. 14. 63-77.

ANTI-DIABETIC EFFECT:

  • Ajabmoor, M.A. Effects of Aloes on blood glucose levels in normal and alloxan diabetic mice. J. Ethnopharmacology. 1990 Feb. 28(2). 215-220.
  • Al-Awadi FM, Guman KA: Studies on the activity of individual plants of an anti-diabetic plant mexture. Acta Diabetol Lat 24:37-42, 1987.
  • Beppu, H.; Nagamura, Y.; Fujita, K. Hypoglycaemic and antidiabetic effects in mice of Aloe arborescens Miller var. natalensis Berger. Phytotherapy Research 1993. 7. No special issue. 837-842.
  • Bunyapraphatsaran N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O.; Antidiabetic activity of Aloe Vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 3:245-248, 1996
  • Davis, R.H.; Leitner, M.G.; Russo, J.M. Aloe Vera (A barbadensis). A natural approach for treating wounds, edema and pain in diabetes. J. Am. Podiatric Med. Assoc. 1988.78(2). 60-68.
  • Davis, R.H.; Maro, N.P. Aloe Vera and gibberellin. Anti-inflammatory activity in diabetes. J. Am. Podiatric Med. Assoc. 1989 Jan. 79 (1). 24-26.
  • Hikino H, Hayashi T: Hypoglycemic polysaccharides extraction from Aloe species, Jpn Kokai Tokkyo Koho, JP 60,214,741, 28 Oct 1985.
  • Hikino H, Takahashi M, Murakami M, Konno C, Mirin Y, Karikura M, Hayashi T: Isolation and hypoglycemic activity of arborans A and B, glycans of Aloe arborescens var, natalensis leaves, Int J Crude Drug Res 24:183-186, 1986.
  • Kalinicheva NV, Shapkina AV: Stimulation of the regeneration of the insular epithelium of the pancreas by some drugs. Tr Leningr Sanit-Gig Med Inst 112:58-64, 1976.
  • Koo, M.W.L Aloe Vera; anti-ulcer and anti-diabetic effects. Phytother Res. 1994. 8(8). 461-464.
  • Youngchaiyudia S.; Rungpitakangsi, V.; Bunyapraphatsaran, et al. Antidiabetic activity of Aloe Vera Juice I. Clinical trial in new cases of Diabetics Mellitus. Phytomedicine. 1996. 3(3) 241-243.
  • Yongchaiyudia S.; Rungpitakangsi, V.; Bunyapraphatsaran, et al. Antidiabetic activity of Aloe Vera Juice II. Clinical trial in new cases of Diabetes Mellitus patients and combination with Glibenclamide Phytomedicine. 1996. 3(3) 245-248.

CARDIOVASCULAR AND LIPID EFFECT:

  • Agarwal, O.P. Preventation of atheromatous heart disease. Angiology. 1985. 36(8) 485-492.
  • Dixit VP, Joshi S: Effect of Aloe Barbadensis and clofibrate on serum lipids in Triniton-induced hyperlipidemia in Presbyter Entellus Entellus Monkeys, Indian J Med Res 78:417-421, 1983.
  • Galal EE, Kandil A, Hegazy E, El Ghoroury M, Gobran W: Aloe Vera and gastrointestinal ulceration, J Drug Res Egypt 7:73-77, 1975.
  • Joshi, S.; Dixit, V.P. Hypolipidaemic effect of Aloe barbadensis Aloe fraction I in cholesterol fed albino rats I. Lipid and lipoprotein metabolism. Proc. Natl. Acad. Sci. India. SB (Biol. Sci) 1988. 56(4) 339-342.
  • Yagi A, Shibata S, Nishioka I, Iwadere S, Ishida Y: Cardiac stimulant action of constituents of Aloe saponaria. J Pharm Sci 71:739-741, 1982.

ANTI-AGEING EFFECT AND EFFECT ON U.V. LIGHT:

  • Danhof I.E. Potential reversal of chronological and phot-ageing of the skin by topical application of natural substances. Phytother Res. 1993. Spec. Issue Proceedings of the International Congress of Phytotherapy, 1991. S53-56.
  • McKeown, E. Anthraquinones and anthracenic derivatives absorb U.V. light. Cosmetics and Toiletries. 1987 June. 102. 64-65
  • Strickland, F.M.; Pelley, R.P.; Kripke, M.L. Prevention of ultraviolet radiation induced suppression of contact and delayed hypersensitivity of Aloe barbadensis gel extract. J. Invest Dermatol. 1997 Feb. 102(2). 197-204.
  • Yagi, A.; Kanbara, R.; Morinobu, N. Inhibition of mushroomtyrosinase by Aloe extract. Planta Medica. 1987. 53(6). 515-517. A10.

ANTHRAQUINONES:

  • Anderson, D.C.; Weber, N.D.; Wood, S.G.; Hughes, B.G.; Murray, B.K.; North, J.A. In vitro virucidal activity of selected Anthraquinones and Anthraquinone derivatives. Antiviral. Res. 1991. Sep. 16(2). 185-96.
  • Anton, R.; Haag-Berrurier, M. Therapeutic use of natural Anthraquinones for other laxative action. Pharmacology 20 (suppl.1) 104-112.
  • Che, Q.M.; Akoa, T.; Hattori, M.; Kobashi, K.; Namba, T. Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. Planta Med. 1991 Feb. 57(1). 15-19.
  • Davis, R.H.; Agnew, P.S.; Shapiro, E. Antiarthritic activity of Anthraquinones found in Aloe for podiatric medicine. J. Am. Podiatric Med. Assoc. 1986. 76(2) 61-66.
  • Davis, R.H.; Leitner, M.G.; Russo, J.M.; Byrne, M.E. Anti inflammatory activity of Aloe Vera against a spectrum of irritants. J.Am. Podiatric Med. Assoc. (US). 1989 June. 79 (6). 263-276.
  • Davis; Kabbani; Maro. Aloe Vera and wound healing. Special emphasis to combination with RNA and Vit. C., consideration of part played by Anthraquinones. J. Am. Podiatric Med. Assoc. 1987. 77(4). 165-169.
  • Malterud, K.C.; Farbrot, T.L.; Huse, A.E.; Sund, R.B. Antioxidant and radical scavenging effects of Anthraquinones and anthrones. Pharmacology. 1993 Oct. 47 (Sipp I.1) 77-85.
  • McKeown, E. Anthraquinones and anthracenic derivatives absorb U.V. light. Cosmetics and Toiletries. 1987 June. 102. 64-65.
  • Sendelbach, L.E. A review of the toxicity and Carcinogenicity of Anthraquinone derivatives. Toxicology. 1989. 57. 227-240. A9.
  • Siegers, C.P.; Siemers, J.; Barettom, G. Senmnosides and Aloin do not promote dimethylhydrazine-induced tumours in mice. Pharacology. 1993 Oct.47 (Suppl. 7) 205-208.
  • Siegers, C.P.; von Hertzberg-Lettim, E.; Otte, M.; Schneider, B. Anthranoid laxative abuse – a risk for colorectal cancer? Gut. 1993 Aug. 34(8) 1099-1101.
  • Sydiskis, R.J.; Owen; Lohr; Rosler; Blomster. Inactivation of Herpes simplex virus by Anthraquinones isolated from plants. J. Dental Res. 1989 June. 68. 935.
  • Westendorf; Marquardt; Poginsky; Dominiak; Schmidt. Genotoxicity of naturally occurring Hydroxyanthraquinones. Evaluation of mutagenicity and cell-transforming activity. Mutat. Res. 1990 Jan. 240(1). 1-12.

SKELETAL SYSTEM:

  • Kadyrov MA, Sharkirov DSH: treatment of fractures by adaptogens under experimental conditions. Eksp Khu Anesteziol 12:50-52, 1967.
  • Shamatov NM: Effect of Aloe extract on the accumulation of Calcium45 and Phosphorus32 in normal and calloused bones, Uckenye Zapiski 2-01 Moskov Med Inst 6:67-69, 1957. Ref. Zh Khim, Biol Khim, 1959, Abstract #3313.